As countries develop their health systems on the path to Universal Health Coverage (UHC) (#LeaveNoOneBehind), many countries are experimenting with the development of a health technology assessment (HTA) agency in order to set priorities for health benefit packages, make go/no go decisions about innovative new health interventions, and/or support pricing negotiations. In this brief, we provide new evidence about the value a HTA agency provides, and suggestions for policy makers about how that value can be measured and enhanced.